The vaginal cream is inserted via applicator once daily, preferably at night, for consecutive days. Therefore, LOTRISONE Cream or Lotion should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. And you know what, my problem was gone overnight! This medication is really an effective one thus highly recommend this for females who have the same problem like just had. Following intravaginal administration of 100 mg 14C-Clotrimazole vaginal tablets to nine adult females, an average peak serum level, clotrimazole kontant ved levering corresponding to only. Carcinogenesis, Mutagenesis, and Impairment of Fertility An 18-month oral dosing study with Clotrimazole in rats has not revealed any carcinogenic effect.