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This list is not complete and there may be other drugs that can interact with Pravachol. Ketoconazole, spironolactone, cimetidine pravachol kjope pravachol that may diminish the levels or activity of steroid hormones. Therapeutic response is seen within week, and the maximum response usually is achieved within weeks. First, as consequence of its reversible inhibition of HMG-CoA reductase activity, it effects modest reductions in intracellular pools of cholesterol.